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Incurin is used for the management of urinary incontinence in spayed bitches.




MSD Animal Health



Prescription Type

POM-V (Written prescription required)

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Reference : MED-00035
Delivery Between 2 and 3 days
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What is Incurin and who is it for?


Incurin is a clear solution for oral use for the management of hormone-dependent urinary incontinence due to sphincter mechanism incompetence in ovariohysterectomised (spayed) bitches.


This is a Prescription only medicine (POM-V).

Incurin is only available with a prescription from your veterinary surgeon.

To check the most up to date information about this product, please read its Summary of Product Characteristics (SPC). It can be viewed here.

What is the active ingredient in Incurin?


Estriol is a short-acting natural oestrogen. In ovarioectomised female dogs it has a beneficial effect on urinary incontinence. In the target animal safety study and the clinical trials, including long-term treatment, no signs of bone marrow suppression were observed. This is probably due to the short-acting oestrogenic character of estriol.


After oral administration Estriol is nearly completely absorbed from gastrointestinal tract. Nearly the whole Estriol is bound to Albumin in Plasma. Estriol is excreted in conjugated form via the urine. After oral administration of multiple doses no accumulation occurs.

30 tablets

What is in Incurin?


Each tablet contains: 

Active substances:

Estriol 1 mg




Potato starch

Magnesium stearate


How do I use Incurin?


Incurin is a prescription product and must be used according to the instructions of your veterinary surgeon.

Please read the product leaflet thoroughly before administering to your pet.

Marketing Authorisation Holder

Intervet International B.V.
The Netherlands


Marketing Authorisation Number


Is there any further advice I should know about Incurin?




Do not use in intact bitches, as the efficacy has only been established in ovariohysterectomised bitches. Animals showing a polyuria-polydipsia should not be treated with Incurin. The use of Incurin is contraindicated during pregnancy, lactation and in animals younger than 1 year.


Special warnings for each target species


High doses of oestrogen may have a tumour-promoting effect in target organs with oestrogen receptors (mammary glands).


Special precautions for use


In case of oestrogenic effects, the dose should be lowered.


Adverse reactions


Oestrogenic effects such as swollen vulva, swollen mammary glands and/or attractiveness to males and vomiting have been observed at the highest recommended dose of 2 mg per dog. The incidence is about 5-9 %. These effects are reversible after lowering the dose. In rare cases vaginal bleeding occurred. In rare cases development of alopecia has also been observed.


Use during pregnancy and lactation


Do not use this product during pregnancy or lactation. See also Contraindications above.


Overdose (symptoms, emergency procedures, antidotes), if necessary


In case of overdose typical oestrogen effects may occur. These effects are reversible after lowering the dose.