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The SERESTO® COLLAR is an odour-free and water resistant, slow release collar for cats. It's designed to protect your pet against fleas and ticks for up to 8 months, it can also be used to treat fleas and help in the management of FAD.







Prescription Type

POM-V (Written prescription required)

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Reference : 2423
Delivery Between 2 and 3 days
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How does it work?

SERESTO® contains imidacloprid and flumethrin. This is released slowly and continuously in low doses by the polymer matrix system of the collar onto your pet's skin and coat, where it forms a protective layer, repelling ticks and fleas.

The SERESTO® COLLAR can be used for the prevention and treatment of fleas and ticks for up to 8 months.


This is a prescription only medication (POM-V)

SERESTO® is only available with a prescription from your veterinary surgeon.

The most up to date Summary of Product Characteristics for this authorised veterinary medicine can be viewed here.

SERESTO® contains Imidacloprid and Flumethrin.

Imidacloprid is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified as a chloronicotinyl nitroguanidine. Imidacloprid is active against larval flea stages, adult fleas and lice. In cats, activity against C.felis starts immediately after application of the collar.n addition to the indications listed under the 'Uses' section, an activity against Pulex irritans fleas has been demonstrated.
Imidacloprid has a high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the central nervous system (CNS) of the flea. The ensuing inhibition of cholinergic transmission in insects results in paralysis and death. Due to the weak nature of the interaction with mammalian nicotinergic receptors and the postulated poor penetration through the blood-brain barrier in mammals, it has virtually no effect on the mammalian CNS. Imidacloprid has minimal pharmacological activity in mammals.
Flumethrin is an ectoparasiticide of the synthetic pyrethroid group. According to current knowledge the synthetic pyrethroids interfere with the sodium channel of nerve cell membranes, resulting in a delay in repolarisation of the nerve and finally killing of the parasite. In studies on structure-activity relationship of a number of pyrethroids, interference with receptors of a certain chiral conformation was noted thereby causing a selective activity on ectoparasites. No anti-cholinesterase activity was noted with these compounds. Flumethrin is responsible for the product’s acaricidal activity and also prevents production of fertile eggs by its lethal effect on female ticks. In an in-vitro study 5 to 10 % of Rhipicephalus sanguineus ticks exposed to a sublethal dose of 4 mg flumethrin/L laid eggs which had a modified appearance (shrivelled, dull and dry) indicating a sterilising effect.
In addition to the indications listed under ‘Uses’ section, activity has been demonstrated in cats against Ixodes hexagonus and the non-European tick species Amblyomma americanum. The product provides repellent (anti-feeding) activity against the claimed ticks, thus preventing repelled parasites from taking a blood meal and thereby indirectly aids in the reduction of the risk of Vector-Borne Disease transmission.
In cats, indirect protection against the transmission of Cytauxzoon felis (transmitted by Amblyomma americanum ticks) has been shown in one laboratory study in a small number of animals at one month after treatment, thereby reducing the risk of diseases caused by this pathogen under the conditions of this study. 
Data from efficacy studies against sand flies (Phlebotomus perniciosus) showed a variable sand fly repellent (anti-feeding) efficacy ranging from 65 to 89% for 7-8 months following initial application of the collar. 
 Both active ingredients are slowly and continuously released in low concentrations from the polymer matrix system of the collar towards the animal. Both actives are present in the cat’s or dog’s haircoat in acaricidal/insecticidal concentrations during the entire efficacy period. The active substances spread from the site of direct contact over the entire skin surface. Target animal overdose and serum kinetic studies have established that imidacloprid reached the systemic circulation transiently while flumethrin was mostly not measurable. Oral absorption of both active substances is not relevant for the clinical efficacy.
One 38cm collar in a recyclable tin container.

Active Substance

One collar of 38cm (12.5g) contains:

Imidacloprid - 1.25g
Flumethrin - 0.56g


Titanium dioxide (E 171)
Iron oxide black (E 172)
Propylene glycol dicaprylocaprate
Epoxidised soybean oil
Stearic acid
Polyvinyl chloride

SERESTO is a prescription product and must be applied according to the instructions by your veterinary surgeon.

Please read the product leaflet thoroughly before applying to your pet.


Bayer plc
Animal Health Division
Bayer House
Strawberry Hill
RG14 1JA


Vm 00010/4173

More information about this medicine for the public can be viewed here.