Protexin Denamarin 425mg Tablets for Large Dogs over 15kg (pack of 30)

PROTEXIN® Denamarin is a nutritional supplement that provides multi-faceted high level liver function support due to its synergistic combination of S-adenosylmethionine (SAMe) and silybin.
Brand Denamarin
Manufacturer Protexin
Species Dog

PROTEXIN® Denamarin is a nutritional supplement that provides support to the liver.  The liver may need supporting when there is disease of the liver, when administering medications that can damage the liver or in any other situation where increased pressure is placed upon the liver.

The synergistic combination of S-adenosylmethionine (SAMe) and silybin help to reduce free radicals and inflammation in the liver.

Denamarin contains:

  • A stabilised form of the S,S-SAMe isomer, the predominant form synthesised in cells and the isomer which is biologically active.
    S-adenosylmethionine (SAMe) increases levels of the major antioxidant glutathione.  Glutathione reduces the damage caused by free radicals in the liver.
    SAMe can increase liver levels of glutathione, important for liver health formed from the metabolisation of SAMe. The SAMe in Denamarin can also protect liver cells and may help cell repair and regeneration.

  • Silybin complexed with phosphatidylcholine, which has been shown to be more bioavailable than silymarin alone. 
    Silybin is the most active flavanoid of silymarin, which is the extract from the milk thistle plant (Silybum marianum).  Silymarin is normally poorly absorbed from the intestine which is why the silybin is combined with phosphatidylcholine to form the SPC complex.  SPC is absorbed much better than silymarin alone. Silybin has been shown to increase glutathione levels as well as having anti-inflammatory effects.

The enteric coating of Denamarin protects the SAMe from degradation. Denamarin is also blister packed to prevent oxidation of the SAMe to the non-biologically active R,S-SAMe isomer. The product is manufactured to high quality standards to ensure the label claim is met.

Box of 30 tablets


Each Tablet Contains

Pack Size SAMe Silybin Additives Composition
Large Dog 425mg  35mg Methione (as S-adenosylmethione) Silybin phytosome (Milk thistle extract/ Phosphatidylcholine complex), Mannitol
Weight Large Dogs
15-30kg 1 tablet
30-55kg 2 tablets
>55kg 3 tablets

The large tablet is 9mm wide at the thickest part, 19.2mm in length, and 7.7mm thick.

The number of tablets administered may gradually be reduced, or increased, at any time at the recommendation of your veterinary surgeon.

Tablets should be given on an empty stomach at least one hour before a meal or 2 hours after food for optimum absorption (an overnight fast is preferred). The reason for this is that the presence of food can reduce the absorption of SAMe.

The enteric-coated tablets have a blue coating around the outside to protect the SAMe and therefore it is important not to break this coating so tablets cannot be split or crushed.  

Store in a cool, dry place. Keep tablets in original blister pack until used. The tablets should not be split or crumbled.

Are there any side effects associated with the use of Denamarin?

Denamarin is a very safe product.  There were no adverse effects noted when Denamarin was given at 80x the recommended levels.  There have been a small number of reports of SAMe causing vomiting in dogs and humans. 

Are there any other medications that cannot be given alongside Denamarin?

Care should be taken when using Denamarin alongside the pain relief medication tramadol.  Please consult your veterinary surgeon before starting Denamarin alongside any medications.

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