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Program Plus is a film-coated tablet specifically designed for dogs. It can be used for the prevention of fleas, and for the concurrent prevention of heartworm and/or treatment of adult stages of gastrointestinal nematodes such as hookworms, roundworms and whipworms. Suitable for small dogs (5-11 kg).







Prescription Type

POM-V (Written prescription required)

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Reference : PP70003
Delivery Between 2 and 3 days
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Program Plus is a film-coated tablet designed for dogs. It can be used for the prevention of fleas, and for the concurrent prevention of heartworm and/or treatment of adult stages of gastrointestinal nematodes, such as hookworms, roundworms and whipworms. Suitable for small dogs (5-11 Kg).

Program Plus should be administered in the following situations:

Puppies: To prevent flea infestations with concurrent heartworm prevention and/or gastrointestinal nematode infection treatment should start from 2 weeks of age, or from a minimum weight of 1 kg.

Dogs in a non-heartworm region:
Program Plus can be used as part of the seasonal prevention of fleas replacing lufenuron mono (PROGRAM tablets) in cases with diagnosed concurrent gastrointestinal nematode infection. After elimination of the nematode infection confirmed by faecal examination, prevention of fleas should continue with PROGRAM tablets if indicated.

In puppies, treatment with Program Plus is recommended up to one month after weaning. Thereafter, prevention of fleas can be continued with lufenuron mono (Program).

Dogs travelling to a heartworm region:
To prevent flea infestations with concurrent heartworm prevention, dogs travelling to a heartworm risk region should begin medication within one month after arrival. Treatment should continue monthly, with the last administration given after the dog has left the region.

Dogs in a heartworm region:
To prevent flea infestations and to prevent heartworm, medication should begin within one month after the appearance of mosquitoes, or one month before the appearance of fleas, and continue throughout the risk period with the last dose given within one month after the mosquito and flea season finishes.
If dogs have a high level of flea infestation at the start of treatment, it may be necessary to apply a flea adulticide during the first one to two months. It is important to treat all dogs and cats in the household for fleas. Cats in the same household should be treated with PROGRAM oral or injectable suspension.

Prescription only medicine.
Program Plus Tablets are only available with a prescription from your veterinary surgeon.
To check the most up to date information about this product, please read its Summary of Product Characteristics (SPC) below:

Milbemycin  belongs to the group of macrocyclic lactones, isolated from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus. Out of the selected analogues, the one currently used for medicinal purposes is Milbemycin A3/A4 oxime (ratio ≤20 : ≥80). As one of the active principles in Program Plus, it is effective against larval stages (L3, L4, and the microfilariae) of Dirofilaria immitis, and anthelmintic activity against the following nematodes: Toxocara canis, Trichuris vulpis, Ancylostoma caninum. The activity of milbemycin is correlated with its action on invertebrate neurotransmission: it potentiates GABA (gamma-amino-butyric acid), an inhibitor of neuromuscular transmission, leading to paralysis.


Lufenuron  belongs to the chemical group of benzoylureas, and is considered an IGR (Insect Growth Regulator) or IDI (Insect Development Inhibitor). It inhibits the development of fleas by interfering with the normal synthesis, polymerisation and deposition of the chitin, the principal component of the arthropod exoskeleton. The adult flea absorbs lufenuron via its bloodmeal. At therapeutic levels, lufenuron has no effect upon adult fleas, but passes transovarially to act upon certain stages of the development of the insect (egg and larva), thus interrupting the insect life cycle. Also, adult flea faeces containing lufenuron exert a larvicidal effect when ingested by the larvae directly.

Pack containing 6 tablets.

Active substances

Milbemycin oxime 5.75 mg

Lufenuron 115.0 mg


Titanium dioxide (E171) 1.9 mg

Program Plus is a prescription product and must be applied according to the instructions by your veterinary surgeon.
Please read the product leaflet thoroughly before applying to your pet.

Marketing Authorisation Holder
Elanco Europe Ltd
Lilly House
Priestley Road
RG24 9NL


Marketing Authorisation Number
Vm 00879/4031

Do not use in case of hypersensitivity to the active substance, to the adjuvants or to any of the excipients.


Special warnings
Ideally, tablets are administered on the same day each month. If an interval is greater than 6 weeks, treatment should be resumed immediately and be continued at monthly intervals and, in case of heartworm prevention, a veterinarian should be consulted.


Special precautions for use in animals
In heartworm risk regions, or in case it is known that a dog has been travelling to and from heartworm risk regions, before commencing PROGRAM Plus treatment as with any other heartworm preventive, a veterinary consultation is advised to exclude the presence of any concurrent infestation of Dirofilaria immitis. In the case of a positive diagnosis, adulticidal therapy is indicated before administering PROGRAM Plus.


Special precautions to be taken by the person administering the veterinary medicinal product to animals
In the case of accidental ingestion seek medical advice immediately and show the package leaflet or the label to the physician.


Adverse reactions (frequency and seriousness)
Pale mucous membranes, increased intestinal peristalsis, lethargy, diarrhea have been observed very rarely after treatment. The treatment of dogs with a high number of circulating microfilariae can sometimes lead to the appearance of moderate and transitory hypersensitivity reactions, such as pale
mucous membranes, vomiting, laboured breathing, or excessive salivation. These reactions are associated with the release of proteins from dead or dying microfilariae and are not a direct toxic effect of the product.


Use during pregnancy, lactation or lay
Can be used during pregnancy.
Can be used during lactation.


Interaction with other medicinal products and other forms of interaction
During treatment with PROGRAM Plus, no other antiparasitic macrocyclic lactones should be administered.