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Profender Spot-on is an antiparasitic liquid application for cats suffering from, or at risk from, mixed parasitic infections caused by roundworms, tapeworms and lungworms. Suitable for small cats (0.5-2.5kg).







Prescription Type

POM-V (Written prescription required)

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Reference : Med-6789299
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Profender Spot-on is an antiparastic liquid application for cats suffering from, or at risk from, mixed parasitic infections caused by roundworms, tapeworms and lungworms. Suitable for small cats (0.5-2.5kg).

Profender Spot-on solution for cats is a clear yellow to brown solution containing 21.4 mg/ml emodepside and 85.8 mg/ml praziquantel, with 5.4 mg/ml butylhydroxyanisole (E320) as antioxidant. The product is presented in a single use plastic tube for dermal (spot-on) application.

Profender spot-on solution for small cats is a 0.35 ml tube containing 7.5 mg emodepside and 30 mg praziquantel.


For use on small cats suffering from, or at risk from, mixed parasitic infections caused by the following species:

Roundworms (Nematodes)

- Toxocara cati (mature adult, immature adult, L4 and L3)

- Toxocara cati (L3 larvae) – treatment of queens during late pregnancy to prevent lactogenic transmission to the offspring

- Toxascaris leonina (mature adult, immature adult and L4)

- Ancylostoma tubaeforme (mature adult, immature adult and L4)

Tapeworms (Cestodes)

- Dipylidium caninum (mature adult and immature adult)

- Taenia taeniaeformis (adult)

- Echinococcus multilocularis (adult)


- Aelurostrongylus abstrusus (adult)


Use During Pregnancy and Lactation

Profender can be used during pregnancy and lactation.


Prescription only medicine.

Profender Spot-on is only available with a prescription from your veterinary surgeon.

To check the most up to date information about this product, please read its Summary of Product Characteristics (SPC) below:

Active ingredients:


Emodepside  is a semi-synthetic compound belonging to the new chemical group of depsipeptides. It is active against roundworms (ascarids and hookworms). In this product, emodepside is responsible for the efficacy against Toxocara cati, Toxascaris leonina, Ancylostoma tubaeforme, and Aelurostrongylus abstrusus. It acts at the neuromuscular junction by stimulating presynaptic receptors belonging to the secretin receptor family which results in paralysis and death of the parasites.


Praziquantel  is a pyrazinoisoquinoline derivative effective against tapeworms such as Dipylidium caninum, Echinococcus multilocularis, and Taenia taeniae formis. Praziquantel is rapidly absorbed via the surface of the parasites and acts primarily by changing the Ca++ permeability of the parasite membranes. This results in severe damage to the parasite integument, contraction and paralysis, disruption of metabolism and finally leads to the death of the parasite.

2 pipettes

Profender Spot-on solution for small cats is a 0.35 ml tube containing 7.5 mg emodepside and 30 mg praziquantel.

Profender Spot-on is a prescription product and must be applied according to the instructions by your veterinary surgeon.

Please read the product leaflet thoroughly before applying to your pet.


Marketing Authorisation Holder

Bayer Animal Health GmbH, 51368 Leverkusen, Germany

Distributed by:

UK: Bayer plc, Animal Health Division, Bayer House, Strawberry Hill, Newbury, Berkshire, RG14 1JA

Ireland: Bayer Ltd, Animal Health Division, The Atrium, Blackthorn Road, Sandyford Ind Est, Dublin 18

Marketing Authorisation Number


Contra-indications, warnings, etc

Do not use in kittens under 8 weeks of age or weighing less than 0.5 kg.

Apply only to the skin surface and on intact skin.

Do not administer orally or parenterally.

Avoid the treated cat or other cats in the household licking the site of application while it is wet.

Salivation and vomiting may occur in very rare cases. Mild and transient neurological disorders such as ataxia or tremor may occur in very rare cases. These effects are thought to occur as a result of the cat licking the application site immediately after treatment. In very rare cases following administration of Profender transient alopecia, pruritus and/or inflammation were observed at the application site.

The frequency of adverse reactions is defined using the following convention:

- very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)

- common (more than 1 but less than 10 animals in 100 animals)

- uncommon (more than 1 but less than 10 animals in 1,000 animals)

- rare (more than 1 but less than 10 animals in 10,000 animals)

- very rare (less than 1 animal in 10,000 animals, including isolated reports).

Salivation, vomiting and neurological signs (tremor) were observed occasionally when the product was administered at up to 10 times the recommended dose in adult cats and up to 5 times the recommended dose in kittens. These symptoms were thought to occur as a result of the cat licking the application site. The symptoms were completely reversible. There is no known specific antidote.

Emodepside is a substrate for P-glycoprotein. Co-treatment with other drugs that are P-glycoprotein substrates/inhibitors (for example, ivermectin and other antiparasitic macrocyclic lactones, erythromycin, prednisolone and cyclosporine) could give rise to pharmacokinetic drug interactions. The potential clinical consequences of such interactions have not been investigated.

Shampooing or immersion of the animal in water directly after treatment may reduce the efficacy of the product. Treated animals therefore should not be bathed until the solution has dried.

There is limited experience on the use of the product in sick and debilitated animals, thus the product should only be used based on a benefit-risk assessment for these animals.

Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.

The solvent in this product may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials.


User Safety

Read the package insert before use.

Do not smoke, eat or drink during application.

Avoid direct contact with application area while it is wet. Keep children away from treated animals during that time.

Wash hands after use.

In case of accidental spillage onto skin, wash off immediately with soap and water.

If the product accidentally gets into eyes, they should be thoroughly flushed with plenty of water.

If skin or eye symptoms persist, or in case of accidental ingestion, seek medical advice and show the package insert or the label to the physician.

Care should be taken not to allow children to have prolonged intensive contact (for example, by sleeping) with treated cats during the first 24 hours after application of the product.

Environmental Safety

Profender should not be allowed to enter water courses as emodepside has shown harmful effects on aquatic organisms.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements."