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Masivet 50mg Tablets (pack of 30)

MASIVET® is a tablet for treatment of dogs with mast-cell tumours (a specific type of cancer).
Brand Masivet
Manufacturer AB Science
Species Dog
Prescription Type POM-V (Written prescription required)
£58.99
In stock
Reference
MA10231

Medication

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Name: Masivet 50mg Tablets (pack of 30)

Description: MASIVET® is a tablet for treatment of dogs with mast-cell tumours (a specific type of cancer).

Description

MASIVET® is a tablet containing mastinib, which belongs to a class of medicines with an anticancer action.

It is prescribed to treat dogs with severe mast-cell tumours.

MASIVET® is only available with a prescription from your veterinary surgeon.

The most up to date Summary of Product Characteristics for this authorised veterinary medicine can be viewed here.

Properties

Mastivet contains mastinib.

Masitinib is a protein-tyrosine kinase inhibitor which, in vitro, potently and selectively inhibits the mutated form, in the juxtamembrane (JM) region, of the c-kit receptor. It also inhibits the Platelet Derived Growth Factor (PDGF) receptor and the Fibroblast Growth Factor Receptor (FGFR3). In the pivotal clinical field study, dogs of various breeds, ranging in age from two to seventeen years, were randomly treated with Masivet at a dose of 12.5 mg/kg or with a placebo. In dogs with nonresectable mast cell tumours, Grade 2 or 3, expressing a mutated tyrosine kinase c-kit receptor, treatment with Masivet showed a significantly longer Time-to-Tumour Progression (TTP) with a median of 241 days as compared to 83 days for placebo. Response to treatment with masitinib was expressed as stable disease; i.e. static, partial or complete response. Masitinib treatment should only be used in dogs with non-resectable mast cell tumours, which express the mutated c-kit tyrosine kinase receptor. The presence of a mutated tyrosine kinase c-kit receptor must be confirmed prior to treatment.

Packaging

Bottle with child-resistant closure cap containing 30 Masivet 50mg film-coated tablets.

Composition

Active Substance

Masitinib 50 mg (equivalent to masitinib mesylate 59.6 mg)

Excipients

Cellulose, microcrystalline
Povidone K30
Pig liver powder
Crospovidone
Magnesium stearate

Tablet coating:
Macrogol 3350
Polyvinyl alcohol
Talc
Titanium dioxide (E171)
Sunset yellow (E110) aluminium lake.

Directions

MASIVET® is a prescription product and must be applied according to the instructions by your veterinary surgeon.

Please read the product leaflet thoroughly before applying to your pet.

Further advice

The European Medicines Agency Summary for the Public for this medicine can be viewed here.

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