Isaderm (formerly Fuciderm) Gel for Dogs 30g
|Prescription Type||POM-V (Written prescription required)|
What is Isaderm and who is it for?
Isaderm (formerly known as Fuciderm) is a white translucent gel that is used for the treatment of surface pyoderma in dogs, such as acute moist dermatitis (‘hot spots’) and intertrigo (skin fold) dermatitis.
This is a Prescription only medicine (POM-V).
Isaderm is only available with a prescription from your veterinary surgeon.
To check the most up to date information about this product, please read its Summary of Product Characteristics (SPC). It can be viewed here.
What are the active ingredients in Isaderm?
Betamethasone valerate is a potent corticosteroid that possesses anti-inflammatory and anti‑pruritic properties.
Fusidic acid has a steroidal structure but does not possess any steroid-like effects. It belongs to the class of antibiotics called Fusidanes. Fusidic acid acts by prohibiting the protein synthesis of bacteria when it binds to elongation factor G (required for translocation on the bacterial ribosome after peptide bond formation during protein synthesis).
Its action is largely bacteriostatic, but at high concentrations (2 to 32-fold higher than the MIC) the effect may be bactericidal. Fusidic acid has activity against Gram‑positive bacteria, namely Staphylococcus spp. (particularly S.pseudintermedius) including penicillinase producing species. It is also active against streptococci.
Two major mechanisms of resistance to fusidic acid have been reported in S. aureus – the alteration of the drug target site which is due to chromosomal mutations in FusA (encoding elongation factor EF-G) or FusE encoding ribosome protein L6, and the protection of the drug target site by FusB family proteins, including fusB, fusC, and fusD. The fusB determinant originally was found on the plasmid in S. aureus but has also been found on a transposon-like element or in a staphylococcal pathogenicity. No cross-resistance between fusidic acid and other antibiotics that are in clinical use has been identified.
In vitro data obtained from a study on dog skin indicates that 17 % of the applied dose of betamethasone and 2.5 % of the applied dose of fusidic acid are absorbed over 48 hours after the administration of the product to the skin. Absorption after administration to inflamed skin is likely to be greater.
What is in Isaderm?
1g of gel contains:
Fusidic acid 5 mg
Betamethasone (as valerate) 1 mg
Methylparahydroxybenzoate (E218) 2.7 mg
Propylparahydroxybenzoate 0.3 mg
How do I use Isaderm?
Isaderm is a prescription product and must be used according to the instructions of your veterinary surgeon.
Please read the product leaflet thoroughly before administering to your pet.
Marketing Authorisation Holder
Snaygill Industrial Estate
Marketing Authorisation Number
Is there any further advice I should know about Isaderm?
Do not use for the treatment of deep pyoderma.
Do not use in pyotraumatic furunculosis and pyotraumatic folliculitis with ‘satellite’ lesions of papules or pustules.
Do not use where fungal or viral infection is present.
Do not apply to the eye.
Do not use over large surface areas or for prolonged treatment.
Do not use in cases of known hypersensitivity to the active substances or to any of the excipients.
Special precautions for use in animals
Official, national and regional antimicrobial policies should be taken into account when the product is used.
Betamethasone valerate can be absorbed percutaneously and may cause temporary suppression of adrenal function.
The dog should be prevented from licking treated lesions and so ingesting the product. Where there is a risk of self-trauma, preventative measures such as the use of an Elizabethan collar should be considered.
Pyoderma is often secondary in nature. The underlying cause should be identified and treated.
It is recommended that use of the product should be based on bacteriological sampling and susceptibility testing. If this is not possible, therapy should be based on epidemiological information about susceptibility of the target bacteria. Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to fusidic acid.
The safety of the combination has not been assessed in puppies of less than 7 months.
Special precautions to be taken by the person administering the product to animals
Corticosteroids may produce irreversible effects in the skin; they can be absorbed and may have harmful effects, especially with frequent and extensive contact or in pregnancy. Pregnant women should take special care to avoid accidental exposure. Always wear single-use disposable gloves when applying this product to animals.Wash hands after having applied the product.
Care should be taken to avoid accidental ingestion by a child. In the case of accidental ingestion, seek medical advice immediately and show the package leaflet to the physician.
Adverse reactions (frequency and seriousness)
Prolonged and intensive use of topical corticosteroid preparations or treatment of a large cutaneous surface (>10%) is known to trigger local or systemic effects including suppression of adrenal function, thinning of the epidermis and delayed healing. Locally applied steroids may cause depigmentation of the skin.
Discontinue use if hypersensitivity develops to the product.
Use during pregnancy, lactation or lay
Laboratory studies showed that topical application of betamethasone in pregnant females may lead to malformations in neonates. The safety of the product has not been assessed during pregnancy and lactation. The use of the product during pregnancy and lactation is not recommended.
Overdose (symptoms, emergency procedures, antidotes), if necessary
For possible signs see Adverse reactions.
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