Advantix 40 for Small Dogs up to 4kg (pack of 4)

ADVANTIX contains Imidacloprid and Permethrin.

For the treatment and prevention of flea (Ctenocephalides canis, Ctenocephalides felis) infestation.

Fleas on dogs are killed within one day following treatment. One treatment prevents further flea infestation for four weeks. The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).

For the treatment of biting lice (Trichodectes canis).

The product has persistent acaricidal and repellent efficacy against tick infestations (Rhipicephalus sanguineus and Ixodes ricinus for four weeks, and Dermacentor reticulatus for three weeks).

Ticks already on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore the removal of ticks already on the dog at the time of treatment is recommended, in order to prevent them from attaching and having a blood meal.

One treatment provides repellent (anti-feeding) activity against sand flies (Phlebotomus papatasi for two weeks and Phlebotomus perniciosus for three weeks), against mosquitoes (Aedes aegypti for two weeks and Culex pipiens for four weeks) and against stable flies (Stomoxys calcitrans) for four weeks.

Imidacloprid is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified as a chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and larval flea stages. In addition to the adulticide flea efficacy of imidacloprid, a larvicidal flea efficacy in the surroundings of the treated pet has been demonstrated. Larval stages in the dog's immediate surroundings are killed following contact with a treated animal. It has a high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the central nervous system (CNS) in insects. The ensuing inhibition of cholinergic transmission in insects results in paralysis and death of the parasite.

Permethrin belongs to the type I class of pyrethroid acaricides and insecticides and also acts as repellent. Pyrethroids affect the voltage-gated sodium channels in vertebrates and non-vertebrates. Pyrethroids are so called “open channel blockers” affecting the sodium channel by slowing both the activation and the inactivation properties thus leading to hyperexcitability and death of the parasite. In the combination of both substances, it has been shown imidacloprid functions as the activator of arthropod ganglia and therefore increases the efficacy of permethrin. The product provides repellent (anti-feeding) activity against ticks, sand flies and mosquitoes, preventing the repelled parasites from taking a blood meal and thus reducing the risk of disease transmission (e.g. borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis). However, there may be an attachment of single ticks or bites by single sand flies or mosquitoes. For this reason, a transmission of infectious diseases by these parasites cannot be completely excluded if conditions are unfavourable.

The product provides repellent (anti-feeding) activity against stable flies thereby assisting in the prevention of fly-bite dermatitis.The product is indicated for dermal administration. Following topical application in dogs, the solution rapidly distributes over the body surface of the animal. Both active substances remain detectable on the skin and hair of the treated animal for 4 weeks. Acute dermal studies in the rat and target animal, overdose and serum kinetic studies have established that systemic absorption of both active substances after application on intact skin is low, transient and not relevant for the clinical efficacy.

ADVANTIX SPOT-ON SOLUTION is a prescription product and must be applied according to the instructions by your veterinary surgeon.

Please read the  product leaflet  thoroughly before applying to your pet.

MARKETING AUTHORISATION HOLDER

Bayer Plc
Animal Health Division
Bayer House
Strawberry Hill
Newbury
Berkshire
RG14 1JA

MARKETING AUTHORISATION NUMBER(S)

Vm 00010/4136