Advantage 250 for Large Dogs (pack of 4)

ADVANTAGE SPOT-ON SOLUTION is an effective topical spot-on used for the treatment and prevention of flea infestations, and the treatment of biting lice in dogs.
Brand Advantage
Manufacturer Bayer
Species Dog
Prescription Type NFA-VPS (Animal details required)

What is Advantage 250 spot-on and who is it for?


ADVANTAGE SPOT-ON SOLUTION contains Imidacloprid, a substance that kills fleas, flea larvae, and lice. It does not affect the nervous system of mammals and has very low systemic absorbance so is safe and effective.

ADVANTAGE SPOT-ON SOLUTION can be used for the prevention and treatment of fleas and the treatment of biting lice (Trichodectes canis) in dogs. It can also be used as part of a treatment strategy for Flea Allergy Dermatitis (FAD), where this has been previously diagnosed by a veterinary surgeon. Additionally, flea larvae in the surroundings of the treated pet are controlled by Advantage.

The most up to date Summary of Product Characteristics for this authorised veterinary medicine can be viewed here.


Please Note: We may need to contact you for some additional information about your pet, before we can dispense this medicine.

What is the active ingredient in Advantage 250 spot-on?


The active ingredient in ADVANTAGE SPOT-ON is Imidacloprid, a substance with a novel and effective mode of action.


What does this ingredient do?


Imidacloprid causes inhibition of cholinergic transmission in the central nervous system (CNS) of insects, resulting in paralysis and death. However due to the biological differences between the CNS of insects and mammals, the substance has virtually no effect on the CNS in mammals.

Flea larvae in the surroundings of the pet are also killed following contact with an animal treated with Advantage Spot-on. 

The solution is indicated for cutaneous (skin) administration. Following topical application, the product is quickly distributed over the animal. Systemic absorption of imidacloprid by the treated animal is very low, transient and not relevant for clinical efficacy. This has been further demonstrated by a study in which fleas were not killed after having fed on previously treated animals once the animal’s skin and fur had been cleaned of all active material.

Box containing four 2.5ml pipettes in a blister pack.

What is in Advantage 250 spot-on?


Active Substance

Imidacloprid: 250mg per 2.5 ml tube


Butylhydroxytoluene (E 321) 2.5 mg/pipette

Benzyl alcohol
Propylene carbonate

How do I use Advantage 250 spot-on?


Apply one tube of ADVANTAGE SPOT-ON 250 per dog weighing from 10 kg to less than 25 kg bodyweight.

Fleas are killed within one day following treatment. One treatment prevents further flea infestation on dogs for up to 4 weeks. Treatment should be repeated after 4 weeks. In case of biting lice infection in dogs, a veterinary examination 30 days after treatment is recommended as some animals may require a second treatment.

 Treatment of nursing bitches controls flea infestations on both dam and offspring.

 The product remains effective if the animal becomes wet, for example after exposure to heavy rain or after swimming (dogs). However, re-treatment may become necessary, depending on the presence of fleas in the environment. In these cases do not treat more frequently than once weekly.

Method of Administration

Remove one tube from the package. Hold tube in an upright position, twist and pull off cap. Use reversed cap to twist and remove seal from tube.

  1. With the dog in the standing position, part the coat between the shoulder blades until the skin is visible.
  2. Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin.

Special precautions for use in animals

For external use only.
Correct application will minimise the opportunity for the animal to lick off the product.
Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.
Care should be taken to avoid the contents of the tube coming into contact with the eyes or mouth of the recipient animal.
Apply only to undamaged skin.
Do not allow recently treated animals to groom each other.

Do not treat unweaned puppies of less than 8 weeks of age.
Do not use in animals that are known to be hypersensitive to the active substance or any of the excipients.

No incompatibility has been observed between this product at twice the recommended dose and the following commonly used veterinary products: lufenuron, febantel, pyrantel and praziquantel (dogs) and lufenuron, pyrantel and praziquantel (cats). The compatibility of the product was also demonstrated with a wide range of routine treatments under field conditions including vaccination.

Studies indicate that no adverse reactions should be expected in pregnant or lactating animals.

Special precautions to be taken by the person administering the medicinal product to animals

This product contains benzyl alcohol and may cause skin sensitisation or transient skin reactions (for example, irritation, tingling).
Avoid contact between the product and skin, eyes or mouth.
Do not eat, drink or smoke during application.
Wash off any skin contamination with soap and water.
If the product gets into eyes accidentally, the eyes should be thoroughly flushed with water.
If skin or eye irritation persists, obtain medical attention.
If the product is accidentally swallowed, obtain medical attention immediately.
Wash hands thoroughly after use.
After application, do not stroke or groom animals until application site is dry.
Store away from food, drink and animal feedingstuffs.

Other precautions

The solvent in this product may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials.

Adverse reactions (frequency and seriousness)

The product is bitter tasting and salivation may occasionally occur if the animal licks the application site immediately after treatment. This is not a sign of intoxication and disappears within a few minutes without treatment.

In rare cases of overdose or licking of treated fur, nervous system disorders (such as twitching, tremors, ataxia, mydriasis, miosis, lethargy) can occur.

Poisoning following inadvertent oral uptake in animals is unlikely. In this event, treatment should be symptomatic under veterinary medical attention. There is no known specific antidote but administration of activated charcoal may be beneficial.

Is there any further advice I should know about Advantage 250 spot-on?


Re-infestation from emergence of new fleas in the environment may continue to occur for six weeks or longer after treatment is initiated. More than one treatment may therefore be required, depending on the level of fleas in the environment. To aid reduction in environmental challenge, the additional use of a suitable environmental treatment against adult fleas and their developing stages is recommended. In order to reduce further the environmental challenge, it is recommended that all dogs, cats and rabbits in the household are treated.

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